allogeneic hematopoietic progenitor cell transplant recipients
نویسندگان
چکیده
From the Department of Transfusion Medicine, the Department of Clinical Immunology, and the Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital at Huddinge, Stockholm, Sweden. Address reprint requests to: Beatrice Diedrich, MD, Transfusion Medicine, C2 66, Karolinska University Hospital at Huddinge, 141 86 Stockholm, Sweden; e-mail: beatrice.diedrich@ karolinska.se. Supported by grants from the Swedish Cancer Society (0070B99-13XAC), the Children’s Cancer Foundation (2000/067, 02/ 074), the Swedish Medical Research Council (K2000-06X-0597120A), the Swedish Foundation for Medical Research (SSMF), the Swedish Society of Medicine (2000-02-0553, 2001-1299), the Cancer Society in Stockholm, and the Tobias Foundation. Received for publication April 30, 2004; revision received December 16, 2004, and accepted December 21, 2004. doi: 10.1111/j.1537-2995.2005.04157.x TRANSFUSION 2005;45:1064-1072. T R A N S F U S I O N P R A C T I C E
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Objectives: Graft versus host disease (GVHD) is a life threatening reaction in the stem cell transplantation process. Nowadays Cyclosporine is the most commonly utilized agent for GVHD prophylaxis and it has a major role in successful transplantation. Cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...
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Allogeneic hematopoietic stem cell transplantation (AHSCT) is a major method of treatmentfor different hematologic and congenital disease. Graft versus host disease (GvHD) is a lifethreateningadverse effect of AHSCT. Cyclosporine is the most important and common agentfor GvHD prophylaxis. Because of variable and unpredictable pharmacokinetics of cyclosporinethat produces...
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